Details of a pioneering IVF technique using mitochondrial replacement therapy (MRT) have been revealed, giving hope to those families with inheritable mitochondrial disorders that they may be able to have healthy children in the future.Read more
When reproductive endocrinologist John Zhang introduced a new in vitro fertilization technique at a medical conference in China in 1997, the audience responded with snickers and modest applause.
Twenty years later, Zhang, 53, made headlines when his team announced the delivery of the world’s first “three-person” baby using a version of the procedure known as mitochondrial replacement therapy.
This is the first baby to be born using a particular "3-parent-baby" technique to treat infertility. With the help of this method, a 34-year-old woman who had suffered from infertility for more than 15 years gave birth to a healthy baby that's genetically her own.Read more
This report summarizes an update on the recent findings on GV transfer pertaining to improving meiotic resump- tion and ability of immature oocytes to mature. It also addresses mitochondrial DNA heteroplasmy as a challenge in GV transfer technology. / John Zhang // Springer Science+Business Media New York 2014Read more
KEY MESSAGE — We report a live birth after oocyte spindle transfer to prevent transmission of the mitochondrial disease, Leigh syndrome. / John Zhang, Hui Liu, Shiyu Luo, Zhuo Lu,
Alejandro Chávez-Badiola, Zitao Liu, Mingxue Yang, Zaher Merhi, Sherman J Silber, Santiago Munné, Michalis Konstandinidis, Dagan Wells, Taosheng Huang
// 2017 Reproductive Healthcare Ltd. Published by Elsevier Ltd