Applied genetic technologies for your family happiness
Nuclear Transfer Background
Nuclear transfer — is a unique approach to the treatment of infertility: it gives hope to give birth to a genetically native child to couples, to whom the reproductive medicine previously could only offer donor eggs.
For today, 2 types of nuclear transfers have been successfully implemented — at the stage of the spindle (John Zang, 2016) and the pronuclear transfer (clinic Nadiya, 2017).
The third way — the transfer of genetic material before the time of full maturation — is in the active stage of the scientific experiment and we hope in the near future to be able to help many women at the age above 42 years old and the birth of a healthy native child without donation of eggs.
Successful Application of Pronuclear Transplantation in Patients with Repeated Failures Following Assisted Reproduction
On December 8, as part of an international meeting of experts on reproductive medicine organized by The International IVF Initiative, Pavlo Mazur, an embryologist at the Nadiya Clinic, made a report on the successful use of pronuclear transplantation in patients with repeated unsuccessful attempts after the use of assisted reproductive technologies.
Webinar: “Is there an Alternative to Egg Donation?”
On March 19, 2019, the webinar: “Is there an Alternative to Egg Donation?” was held. This event united people who considered the use of donor oocyte for the treatment of infertility or the prevention of mitochondrial pathology and leading world-class experts from Ukrainian and Israel.
On September 17, 2018, an interview was conducted on the channel UA:Pershy: The top theme about the newest method of infertility treatment – Nuclear transfer.
On September 17, 2018, an interview was conducted on the channel UA:Pershy with the participation of Executive Director of “Darwin Life-Nadiya” Dmytro Mykytenko, MD, D.Sc. and Embryologist of the Clinic of reproductive medicine “Nadiya” Pavlo Mazur. The interviewers discussed the top theme about the newest method of infertility treatment - Nuclear transfer.
THE DOCTOR WHO DELIVERED THE WORLD’S FIRST ‘THREE-PERSON’ BABY
When reproductive endocrinologist John Zhang introduced a new in vitro fertilization technique at a medical conference in China in 1997, the audience responded with snickers and modest applause. “[They] told me my head was in the clouds,” Zhang recalls.
Three-Parent Babies Actually Exist — & This Is How They’re Conceived
Last year, John Zhang, a New York endocrinologist who specializes in fertility, generated controversy when he announced that he helped a couple in Mexico have the first baby conceived with the genetic material of three different adults.
Fertility doctor offering to blend eggs from two women to make ‘three-parent’ babies
Dr. John Zhang is offering women in their 40s a “solution” for age-related infertility — swapping chromosomes between two women’s eggs, resulting in a child with, technically speaking, three genetic parents
First baby born using 3-parent technique to treat infertility
This is the first baby to be born using a particular “3-parent-baby” technique to treat infertility.
The girl was born on 5 January in a fertility clinic in Kiev, Ukraine. “With the help of this method, a 34-year-old woman who had suffered from infertility for more than 15 years gave birth to a healthy baby that’s genetically her own,” said a statement from the Nadiya clinic
Three-parent baby born to ‘infertile’ woman using controversial new IVF
Thousands of British couples who are struggling to have children could benefit from a new “three-parent” IVF technique that has enabled a previously infertile woman to give birth. Doctors announced yesterday that a healthy boy had been delivered after the world’s first operation of its kind, but some scientists warned that the treatment could be unsafe and could give women false hope.
IVF: First three-parent baby born to infertile couple
Doctors in Kiev used a method called pronuclear transfer in what is a world first. It is, however, not the first child born with DNA from three parents. The baby girl, born on 5 January, is thought to be the world's second "modern three-parent baby" - another child was created using a slightly different method in Mexico last year.
Three-parent baby born to ‘infertile’ woman using controversial new IVF — The Times
Thousands of British couples who are struggling to have children could benefit from a new "three-parent" IVF technique that has enabled a previously infertile woman to give birth.
A baby has been born to a previously infertile couple in Ukraine using a new type of "three-person". Doctors in Kiev used a method called pronuclear transfer in what is a world first.
Controversial IVF technique produces a baby girl — CNN
It was a first for the entire world: Using a controversial in vitro fertilization technique, doctors in Kiev, Ukraine, helped a previously infertile couple conceive and deliver a baby girl.
Technique for ‘three-parent baby’ revealed — Science Daily
Details of a pioneering IVF technique using mitochondrial replacement therapy (MRT) have been revealed, giving hope to those families with inheritable mitochondrial disorders that they may be able to have healthy children in the future.
The Doctor Who Delivered The World’s First ‘Three-Person’ Baby — OZY.COM
When reproductive endocrinologist John Zhang introduced a new in vitro fertilization technique at a medical conference in China in 1997, the audience responded with snickers and modest applause.
Twenty years later, Zhang, 53, made headlines when his team announced the delivery of the world’s first “three-person” baby using a version of the procedure known as mitochondrial replacement therapy.
First baby born using 3-parent technique to treat infertility — New Scientist
This is the first baby to be born using a particular "3-parent-baby" technique to treat infertility. With the help of this method, a 34-year-old woman who had suffered from infertility for more than 15 years gave birth to a healthy baby that's genetically her own.
Revisiting Germinal Vesicle Transfer as a Treatment for Aneuploidy in Infertile Women with Diminished Ovarian Reserve — Article
This report summarizes an update on the recent findings on GV transfer pertaining to improving meiotic resump- tion and ability of immature oocytes to mature. It also addresses mitochondrial DNA heteroplasmy as a challenge in GV transfer technology. / John Zhang // Springer Science+Business Media New York 2014
Live birth derived from oocyte spindle transfer to prevent mitochondrial disease — Article
KEY MESSAGE — We report a live birth after oocyte spindle transfer to prevent transmission of the mitochondrial disease, Leigh syndrome. / John Zhang, Hui Liu, Shiyu Luo, Zhuo Lu, Alejandro Chávez-Badiola, Zitao Liu, Mingxue Yang, Zaher Merhi, Sherman J Silber, Santiago Munné, Michalis Konstandinidis, Dagan Wells, Taosheng Huang
// 2017 Reproductive Healthcare Ltd. Published by Elsevier Ltd
Darwin Life-Nadiya is a united team of US and Ukrainian scientists who have combined experience in molecular genetics, embryology and human reproduction to develop the newest methods for achieving the pregnancy with a healthy baby in women with the high risk of mitochondrial pathology in their offspring, as well as in complicated cases of infertility forms with high genetic risk. Experimental technology of the nuclear transfer allows:
to receive a genetically native embryo for parents with healthy mitochondria in case of the high risk transmission of mitochondrial pathology;
to reduce the risk of egg meiotic chromosomal abnormalities associated with age factors;
minimize the genetically-associated effects of the block maturation of eggs and development of embryos.
Board of directors
Dr. John Zhang
MD, PhD, MSc, Chief Medical Officer, CEO of Darwin Life
Dr. Valery Zukin
MD, PhD, Director of Nadiya clinic of reproductive medicine
Scientific committee
Hui Liu
MD, MSc,Darwin life Chief Research Scientist, USA
Dmytro Mykytenko
M. D., D. Sc., Assoc. Prof., National Medical University, Department of Social Medicine and Public Health
Stoyana Alexandrova
PhD, Darwin life Senior Research Scientist and Project Manager, USA
Pavlo Mazur
Senior Research embryologists, Clinic of reproductive medicine NADIYA, Ukraine
Lada Dyachenko
Research embryologists, Clinic of reproductive medicine NADIYA, Ukraine
Zhuo Lu
PhD, Senior Embryologist, New Hope Fertility Center, USA